The new issue of the Association for Psychological Science's journal *Perspectives on Psychological Science* includes an article: "How Does Mindfulness Meditation Work? Proposing Mechanisms of Action From a Conceptual and Neural Perspective ."

The authors are Britta K. Holzel, Sara W. Lazar, Tim Gard, Zev Schuman-Olivier, David R. Vago, and Ulrich Ott.

Here's how the article begins:

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Mindfulness meditation has been reported to produce beneficial effects on a number of psychiatric, functional somatic, and stress-related symptoms and has therefore increasingly been incorporated into psychotherapeutic programs (cf., Baer, 2003; Grossman, Niemann, Schmidt, & Walach, 2004).

A large body of research documents the efficacy of mindfulness-based interventions in the treatment of a number of clinical disorders, including anxiety (Hofmann, Sawyer, Witt, & Oh, 2010; Roemer, Orsillo, & Salters-Pedneault, 2008), depression (Hofmann et al., 2010; Teasdale et al., 2000), substance abuse (Bowen et al., 2006), eating disorders (Tapper et al., 2009), and chronic pain (Grossman, Tiefenthaler-Gilmer, Raysz, & Kesper, 2007).

Furthermore, mindfulness meditation positively influences aspects of physical health, including improved immune function (Carlson, Speca, Faris, & Patel, 2007; Davidson et al., 2003), reduced blood pressure and cortisol levels (Carlson et al., 2007), and increased telomerase activity1 (Jacobs et al., 2010).

Not only has mindfulness successfully been used in the treatment of disorders and improvement of health; it has also been shown to produce positive effects on psychological well-being in healthy participants (Carmody & Baer, 2008; Chiesa & Serretti, 2009) and to enhance cognitive functioning (Jha, Krompinger, & Baime, 2007; Ortner, Kilner, & Zelazo, 2007; Pagnoni & Cekic, 2007; Slagter et al., 2007).

Historically, mindfulness is a concept stemming from ancient Buddhist philosophy (Bhikkhu, 2010), and is practiced to achieve enduring happiness (Ekman, Davidson, Ricard, & Wallace, 2005) and to gain insight into a view of the true nature of existence (Olendzki, 2010).

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In current research contexts, mindfulness is typically defined as nonjudgmental attention to experiences in the present moment (Kabat-Zinn, 1990).

Bishop et al. (2004) suggest a two-component model of mindfulness, where the first component is the regulation of attention in order to maintain it on the immediate experience, and the second component involves approaching one's experiences with an orientation of curiosity, openness, and acceptance, regardless of their valence and desirability.

Mindfulness is typically cultivated in formal meditation practices, such as sitting meditation, walking meditation, or mindful movements (Kabat-Zinn, 1990).

The practice of mindfulness meditation encompasses focusing attention on the experience of thoughts, emotions, and body sensations, simply observing them as they arise and pass away.

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Several neuroscientific studies have reported the ACC to be implicated in meditation (Cahn & Polich, 2006). Using functional MRI (fMRI), Holzel et al. (2007) pursued the question of which brain region would be distinctly activated when meditators performed focused attention meditation.

Compared with age-, gender-, and education-matched controls, experienced meditators showed greater activation in the rostral ACC (Holzel et al., 2007), suggesting an effect of meditation practice on ACC activity.

A similar effect (greater rostral ACC activation in meditators compared with controls) was identified when individuals engaged in a mindfulness practice while awaiting unpleasant electric stimulation (Gard et al., 2010).

Five days of Integrative Body-Mind Training may lead to greater activation of the rostral ACC during the resting state (Tang et al., 2009).

Although ACC activation might initially be enhanced when acquiring greater attentional control, it might later decrease with higher levels of expertise, when the focus of attention is so steady that monitoring distractions becomes superfluous (Brefczynski-Lewis, Lutz, Schaefer, Levinson, & Davidson, 2007).

In addition to these functional findings, structural MRI data also indicate that meditation practice might exert an influence on the ACC.

Cortical thickness in the dorsal ACC was greater in experienced meditators compared with control subjects in an analysis of brain gray matter (Grant, Courtemanche, Duerden, Duncan, & Rainville, 2010), and 11 hr of Integrative Body-Mind Training led to an increase in white matter integrity in the ACC (Tang et al., 2010).

In line with the assumption that ACC function is strengthened through concentrative meditation, electroencephalogram data document increased frontal midline theta rhythm during meditation (Aftanas & Golocheikine, 2002; Kubota et al., 2001).

Frontal midline theta is associated with attention demanding tasks and presumably reflects ACC (and medial prefrontal cortex) activity (Asada, Fukuda, Tsunoda, Yamaguchi, & Tonoike, 1999).

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Here's how the article ends: "Mindfulness as a state, trait, and clinical intervention has been extensively researched over the last two decades; however, knowledge of the underlying mechanisms of mindfulness is still in its infancy. Future work should identify additional components of mindfulness and establish to what extent the components described in this article are truly distinct mechanisms or how they can be integrated into fewer components. We believe that it will be necessary both to further differentiate each component and to further integrate them into a comprehensive model. This future empirical work is critical in order to optimally apply mindfulness in the clinical domain and to advance techniques that aim at cultivating a healthy mind and increased well-being."

The author note provides the following contact info: Britta K. Holzel, Bender Institute of Neuroimaging, Justus Liebig-University, Otto-Behaghel-Str. 10 H, 35394 Giessen, Germany E-mail: <britta@nmr.mgh.harvard.edu>.

Ken Pope